yes and no
I started with a methanol tune from day one so I just changed all the AFR tables and offset tables to be 2.3 times that of petrol AFR tables then I tuned the VE from there.....
I do run it on E85 when not racing just because its easy to get from a local servo and cheaper than methanol etc .... and all I did for that was changed the same AFR tables for E85 and then uploaded the changed calibration and fired it up on E85.
its not perfect but then its a race car so I am not driving it every day to get enough time to get it spot on.
assuming your VE table is right for your motor and nothing else is out of whack like injector offsets and such, then you should be able to just swap AFR numbers in the tune and go from there.
as far as making changes to my tunes, I only ever change the one methanol racing tune that I have, for improvements in VE / Boost VE tables then if I do change them I just bring that over to the E85 tune I have by comparing the two in tunerpro.....
and I have two separate tunes as I use map a/b switching in my tune to change spark and AFR's when on the 2 step rev limiter, then when I let the button off I go back to map a AFR and spark and they are both methanol.
I also have a VL400 data logger in the car full time so I just have each of the tunes on the SD card and just upload as I need (20 seconds pretty much the change the tune over)
when I first started with methanol though I did play around with having map b as methanol and map a as petrol, and what I'd do is flush the system and then add petrol, and then start the motor and when it got really rich on the wideband I'd flick the switch to change to petrol AFR's and it would then just run as normal on petrol, and pretty much the same thing going back to methanol.
this was all with $12P