I might have found an issue wiith Windows 10 x64 using TP5 RT 5.00.8713 (paid) and the OSEPlugin v1.50?
I have one of VL400 NVRam boards and could communicate with this via TP5 and flash etc last week no worries.
Changes made to Laptop in last 7 days are updated to Windows 10 and also newer version of TP5. Now get pop up screen and I can gain access to ECU at all?
Troubleshooting so far:
Tried TP5 in compatibility mode, Windows 7, 8 no dice!

Tried OSE Enhanced Flash Tool V151 to access bin. = Success, no worries at all. Wrote back also.

Tried Microsoft VC 10 runtime install as per Antus suggestions for Dylan on early page of this tread. = Success!
Link I used: http://www.microsoft.com/en-us/download ... x?id=26999
Hope this helps other early adopters...

Andrew